Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylate → 4-Bromo-5-(3-chlorophenyl)furan-2-carboxylic acid

HRID 2190127Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2190127
ClC1C=C(C2C=C(C(O)=O)OC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Br:25][C:26]1[CH:27]=[C:28]([C:38]([O:40]CC)=[O:39])[O:29][C:30]=1[C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[CH:32]=1>>[Br:25][C:26]1[CH:27]=[C:28]([C:38]([OH:40])=[O:39])[O:29][C:30]=1[C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[CH:32]=1

Komponenten

3

Edukt 2

HCID 58064772Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylateHCID 580647984-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acid

Produkt 1

HCID 580647974-Bromo-5-(3-chlorophenyl)furan-2-carboxylic acid

Versuchsvorschrift

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 20A starting with the compound from Example 5A. Instead of using ethyl acetate, the crude product is extracted with dichloromethane and reacted further without chromatographic purification. 447 mg (98% of theory) of the title compound are obtained.

Aufarbeitung

  1. extractionInstead of using ethyl acetate, the crude product is extracted with dichloromethane
  2. customreacted further without chromatographic purification

Quellen und Nachweise

ORD-Eintrag
ord-99678ff6324c49449c7f0cf733311f55
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324268B2

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