tert-Butyl piperazine-1-carboxylate → N-(3-tert-Butyl-phenyl)-2-methyl-4-piperazin-1-yl-benzamide

HRID 2190549Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2190549
Br[C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([CH3:18])([CH3:17])[CH3:16])[CH:10]=2)=[O:7])=[C:4]([CH3:21])[CH:3]=1.C(OC([N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)=O)(C)(C)C.C(C1C=C(NC(=O)C2C=CC(N3CCNCC3)=C(F)C=2)C=CC=1)(C)(C)C>>[C:15]([C:11]1[CH:10]=[C:9]([NH:8][C:6](=[O:7])[C:5]2[CH:19]=[CH:20][C:2]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[CH:3][C:4]=2[CH3:21])[CH:14]=[CH:13][CH:12]=1)([CH3:18])([CH3:17])[CH3:16]

Komponenten

4

Edukt 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 59318037N-(3-tert-Butyl-phenyl)-3-fluoro-4-piperazin-1-yl-benzamideHCID 593180964-bromo-N-(3-tert-butyl-phenyl)-2-methyl-benzamide

Produkt 1

HCID 59318133N-(3-tert-Butyl-phenyl)-2-methyl-4-piperazin-1-yl-benzamide

Versuchsvorschrift

N-(3-tert-Butyl-phenyl)-2-methyl-4-piperazin-1-yl-benzamide was synthesized from 4-bromo-N-(3-tert-butyl-phenyl)-2-methyl-benzamide and piperazine-1-carboxylic acid tert-butyl ester in a manner similar to the one described in the synthesis of N-(3-tert-butyl-phenyl)-3-fluoro-4-piperazin-1-yl-benzamide above. LCMS calcd for C22H29N3O (m/e) 351, obsd 352 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-3004f5c7054c4d92baccc6be4ebe2cd5
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324385B2

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