Sodium Glycinate → [(4-Hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carbonyl)-amino]-acetic acid

HRID 2190910

Reaktionsgleichung

Reaktionsgleichung von HRID 2190910
C(O[C:4]([C:6]1[C:7](=[O:24])[O:8][C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11]([O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH:10]=2)=[O:5])C.[NH2:25][CH2:26][C:27]([O-:29])=[O:28].[Na+]>COC(O)C>[OH:16][C:15]1[C:14]2[C:9](=[CH:10][C:11]([O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:12][CH:13]=2)[O:8][C:7](=[O:24])[C:6]=1[C:4]([NH:25][CH2:26][C:27]([OH:29])=[O:28])=[O:5]

Komponenten

4

Edukt 2

HCID 4684308Sodium GlycinateHCID 866494634-Hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carboxylic acid ethyl ester

Produkt 1

HCID 54746545[(4-Hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carbonyl)-amino]-acetic acidAusbeute 105,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 30156371-MethoxyethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carboxylic acid ethyl ester (84 mg, 0.248 mmol) and sodium glycinate (121 mg, 1.24 mmol) in methoxyethanol (5 mL) was refluxed for 15 h; then cooled, the solvent was removed, the residue was redissolved in water, acidified with 2 M HCl, the precipitates were collected and freeze dried to give the desired title product (93 mg). ESI (m/z): 356 (M+H)+.

Aufarbeitung

  1. temperaturewas refluxed for 15 h
  2. temperaturethen cooled
  3. customthe solvent was removed
  4. dissolutionthe residue was redissolved in water
  5. customthe precipitates were collected
  6. customfreeze dried

Quellen und Nachweise

ORD-Eintrag
ord-a0e542033fb84b4fa4e6abcd8255e9c0
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324405B2

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