HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 219153Erstellt: 24. Oktober 2026
Dimethylformamide → 7-(difluoromethoxy)-N-((6-phenyl-[1,2,4]-triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine
https://huagongshe.com/de/reaction/219153
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | Sodium chlorodifluoroacetate | HCID 2734985 | — |
| Edukt | 8-((6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methylamino)-1,5-naphthyridin-3-ol | HCID 135987478 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | 7-(difluoromethoxy)-N-((6-phenyl-[1,2,4]-triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | HCID 57691349 | 17,7% |
Reaktionsschritte
DMF (0.5 mL) and water (0.1 mL) were added to a pressure vessel containing 8-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methylamino)-1,5-naphthyridin-3-ol (50 mg, 135 μmol), sodium 2-chloro-2,2-difluoroacetate (47 mg, 311 μmol), cesium carbonate (62 mg, 190 μmol). The reaction mixture was stirred at 100° C. for 18 h, cooled to RT and concentrated in vacuo. Purification by MPLC (DCM/MeOH+1% NH4OH: 100/0 to 90/10) afforded the title compound (10 mg, 17% yield). MS m/z=420.1 [M+H]+. Calc'd for C21H15F2N7O: 419.40.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08198448B2 |
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| Quelldatensatz | uspto-grants-2012_06 |
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| ORD ID | ord-07c3e49acd4a4b2ebfb3ba18d2df86b6 |
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| Quellennotiz | uspto-grants-2012_06 |
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