Trifluoroacetic acid → HCID 57667846, Verbindung

HRID 2191818Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2191818
FC(F)(F)C(O)=O.C(OC([O:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:34]=[CH:33][C:25]([C:26]([O:28]C(C)(C)C)=[O:27])=[C:24]([NH:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([OH:42])[CH:37]=3)[CH:23]=2)[CH:19]=[CH:20][CH:21]=1)=O)(C)(C)C>>[OH:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:34]=[CH:33][C:25]([C:26]([OH:28])=[O:27])=[C:24]([NH:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([OH:42])[CH:37]=3)[CH:23]=2)[CH:19]=[CH:20][CH:21]=1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68963254HCID 68963254, Verbindung

Produkt 1

HCID 57667846HCID 57667846, Verbindung

Versuchsvorschrift

Trifluoroacetic acid 5.0 mL was added to the obtained tert-butyl 4-(3-(tert-butoxycarbonyl)oxyphenyl)-2-((3-hydroxyphenyl)amino)benzoate, and it was stirred at room temperature for 3 hours. The solvent was removed under reduced pressure, hexane and diisopropyl ether were added to the obtained residue, and solid matter was filtrated to give 4-(3-hydroxyphenyl)-2-((3-hydroxyphenyl)amino)benzoic acid 10 mg of a yellow solid.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure, hexane and diisopropyl ether
  2. additionwere added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Quellen und Nachweise

ORD-Eintrag
ord-e1be98da4bf4461f8d2f72eaa4f7edd0
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08327467B2

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