CID 6037 → HCID 178484386, Verbindung

HRID 2191896

Reaktionsgleichung

Reaktionsgleichung von HRID 2191896
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[CH:10]1[C:15]([C:16]([NH:18][C@H:19]([C:25]([OH:27])=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:17])=[CH:14][CH:13]=[C:12]([NH:28][CH2:29][C:30]2[CH:31]=[N:32][C:33]3[NH:40][C:39]([NH2:41])=[N:38][C:36](=[O:37])[C:34]=3[N:35]=2)[CH:11]=1>C(O)C>[CH:14]1[C:15]([C:16]([NH:18][C@H:19]([C:25]([OH:27])=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:17])=[CH:10][CH:11]=[C:12]([NH:28][CH2:29][C:30]2[CH:31]=[N:32][C:33]3[NH:40][C:39]([NH2:41])=[N:38][C:36](=[O:37])[C:34]=3[N:35]=2)[CH:13]=1.[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3]

Komponenten

4

Edukt 2

HCID 6037CID 6037HCID 178484382HCID 178484382, Verbindung2×

Produkt 1

HCID 178484386HCID 178484386, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel3×

Versuchsvorschrift

Under nitrogen gas, 150 mL fresh ethanol was added to the free base of metformin in ethanol, and to the free base of metformin in ethanol was slowly added 42 g (0.095 eq.) folacin solid. At that time the temperature of the reaction mixture began to ascend. The reaction was stirred and the adding speed was controlled to keep the reaction temperature not exceeding 50° C. Stirring was continued until the solid was substantially dissolved. When new solid began to present, ⅔-⅘ volume of solvent was removed under reduced pressure, and the reaction was cooled to ambient temperature to give the crude product of folacin-metformin compound.

Aufarbeitung

  1. customexceeding 50° C
  2. stirringStirring
  3. dissolutionwas substantially dissolved
  4. custom⅔-⅘ volume of solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ea37497c9b484071a21980134ca89a4a
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08329710B2

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