Sodium Hydroxide → 3-Fluoro-4-{[3-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}aniline
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]([NH:22]C(=O)C)[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:15][CH:16]=[C:17]([CH2:18][CH2:19][O:20][CH3:21])[C:10]=12.[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:15][CH:16]=[C:17]([CH2:18][CH2:19][O:20][CH3:21])[C:10]=12)[NH2:22]Komponenten
4
Reaktionsbedingungen
- Temperatur
- 90 °C
Versuchsvorschrift
63 mg (0.18 mmol) of N-(3-fluoro-4-{[3-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}phenyl)acetamide are dissolved in 5 ml of ethanol. 2 ml of 20% strength aqueous sodium hydroxide solution are added, and the mixture is stirred at 90° C. overnight. The reaction mixture is then partitioned between ethyl acetate and 1N aqueous sodium hydroxide solution. The aqueous solution is extracted with ethyl acetate and the combined organic phases are washed with 1N aqueous sodium hydroxide solution. The organic phases are dried over magnesium sulfate and the solvent is removed under reduced pressure. The product is reacted further without purification.
Aufarbeitung
- customThe reaction mixture is then partitioned between ethyl acetate and 1N aqueous sodium hydroxide solution
- extractionThe aqueous solution is extracted with ethyl acetate
- washthe combined organic phases are washed with 1N aqueous sodium hydroxide solution
- dry with materialThe organic phases are dried over magnesium sulfate
- customthe solvent is removed under reduced pressure
- customThe product is reacted further without purification
Quellen und Nachweise
- ORD-Eintrag
- ord-50bf8ad04cd8421a9686db483d298bdc
- Quelldatensatz
- uspto-grants-2012_12
- Patentnummer
- US08329716B2
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