Imidazole → 5-(t-Butyldimethylsiloxy)-3-pentyne

HRID 21923

Reaktionsgleichung

Reaktionsgleichung von HRID 21923
[CH2:1]([OH:5])[CH2:2][C:3]#[CH:4].[Si:6](Cl)([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7].N1C=CN=[CH:15]1>CN(C=O)C>[O:5]([CH2:1][C:2]#[C:3][CH2:4][CH3:15])[Si:6]([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7]

Komponenten

5

Edukt 3

HCID 795ImidazoleHCID 135663-Butyn-1-OLHCID 28928tert-Butyldimethylsilyl chloride

Produkt 1

HCID 110198575-(t-Butyldimethylsiloxy)-3-pentyne

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 3-butyn-1-ol (g) (10.0 g) in DMF (80 ml) were added t-butyldimethylsilyl chloride (21.5 g) and imidazol (10.6 g), and the resultant mixture was kept at 35° C. for 7 hours. The reaction mixture was treated in the conventional manner and the obtained crude product was distilled to give the title compound (h).

Aufarbeitung

  1. additionThe reaction mixture was treated in the conventional manner
  2. customthe obtained crude product
  3. distillationwas distilled

Quellen und Nachweise

ORD-Eintrag
ord-f6de6665a81f41a69e382a42c905148e
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05426115

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