Sodium Hydroxide → 1-Isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid

HRID 2192484Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2192484
[OH-].[Na+].[CH3:3][CH:4]([CH3:17])[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([C:12]([O:14]C)=[O:13])=[CH:8][C:7]1=[O:16]>CO>[CH3:3][CH:4]([CH3:17])[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][C:7]1=[O:16]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 59214340HCID 59214340, Verbindung

Produkt 1

HCID 446005741-Isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylic acidAusbeute 95,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A 2M aqueous solution of sodium hydroxide (5.38 ml, 10.75 mmol) was added to a solution of methyl 1-(2-methylpropyl)-2-oxo-1,2-dihydro-4-pyridinecarboxylate (D27; 0.45 g, 2.151 mmol) in methanol (10 ml). The mixture was stirred at room temperature for 2 hrs and then the solvent was removed under vacuum. The residue was taken up with water, neutralised with 2M HCl and extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulphate and concentrated under vacuum to give the title compound as a white solid (400 mg).

Aufarbeitung

  1. customthe solvent was removed under vacuum
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialdried over magnesium sulphate
  5. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-80a094f04e5c448c801008136ebf029e
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08329730B2

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