Hydrogen chloride-ethyl acetate → HCID 68432330, Verbindung

HRID 2192786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2192786
[NH2:1][C:2]([C@@H:4]1[CH2:9][C@H:8]([N:10]([C:15]([C:17]2[C:18]([NH:27][CH2:28][C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[N:19][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[N:21][CH:22]=2)=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5]1)=[O:3].C(OCC)(=O)C.[ClH:47]>>[ClH:47].[ClH:47].[NH2:1][C:2]([C@@H:4]1[CH2:5][NH:6][CH2:7][C@H:8]([N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:15]([C:17]2[C:18]([NH:27][CH2:28][C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[N:19][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[N:21][CH:22]=2)=[O:16])[CH2:9]1)=[O:3]

Komponenten

3

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59625490tert-butyl (3R*,5S*)-3-(aminocarbonyl)-5-[({2-tert-butyl-4-[(2-furylmethyl)amino]pyrimidin-5-yl}carbonyl)(isobutyl)amino]piperidine-1-carboxylate

Produkt 1

HCID 68432330HCID 68432330, Verbindung

Versuchsvorschrift

tert-Butyl (3R*,5S*)-3-(aminocarbonyl)-5-[({2-tert-butyl-4-[(2-furylmethyl)amino]pyrimidin-5-yl}carbonyl)(isobutyl)amino]piperidine-1-carboxylate (230 mg) was dissolved in 1 M hydrogen chloride-ethyl acetate (4 ml), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, ethyl acetate was added and the precipitate was collected by filtration and washed with ethyl acetate to give the object compound (218 mg).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. additionethyl acetate was added
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-3ef6f23b6d3d44dabd872fffb81d7810
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08329691B2

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