3,5-Dimethylisoxazole-4-sulfonyl chloride → 8-(3,5-Dimethyl-isoxazole-4-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194167

Reaktionsgleichung

Reaktionsgleichung von HRID 2194167
C(O)(=O)C.[F:5][C:6]([F:26])([F:25])[O:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:18][CH2:17][C:16]3([CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:15]2=[O:24])=[CH:10][CH:9]=1.[CH3:27][C:28]1[C:32]([S:33](Cl)(=[O:35])=[O:34])=[C:31]([CH3:37])[O:30][N:29]=1>>[CH3:27][C:28]1[C:32]([S:33]([N:21]2[CH2:20][CH2:19][C:16]3([C:15](=[O:24])[N:14]([C:11]4[CH:12]=[CH:13][C:8]([O:7][C:6]([F:5])([F:25])[F:26])=[CH:9][CH:10]=4)[CH2:18][CH2:17]3)[CH2:23][CH2:22]2)(=[O:35])=[O:34])=[C:31]([CH3:37])[O:30][N:29]=1

Komponenten

3

Edukt 2

HCID 27363193,5-Dimethylisoxazole-4-sulfonyl chlorideHCID 667873332-(4-Trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetic acid salt

Produkt 1

HCID 595779878-(3,5-Dimethyl-isoxazole-4-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Versuchsvorschrift

The title compound was prepared in analogy to example 180 step D from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetic acid salt (described in example 180 step C) and 3,5-dimethyl-isoxazole-4-sulfonyl chloride. White solid. MS (ESI): 474.2 (MH+)

Quellen und Nachweise

ORD-Eintrag
ord-01f0a819abfc48848af5921f64eb1932
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08329904B2

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