HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(4-Bromophenyl)cyclobutanol → 8-(2-Chloro-benzenesulfonyl)-2-[4-(1-hydroxy-cyclobutyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(4-Bromophenyl)cyclobutanol | HCID 12095419 | — |
| Edukt | 8-(2-Chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 59577994 | — |
| Produkt | 8-(2-Chloro-benzenesulfonyl)-2-[4-(1-hydroxy-cyclobutyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 59577918 | — |
Reaktionsschritte
The title compound was prepared in analogy to example 148 step F) from 8-(2-chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 148 step E or example 179 step A for an alternative synthesis) and 1-(4-bromo-phenyl)-cyclobutanol (prepared as described in SYNLETT 2004, No. 8, pp 1440-1442). White solid. MS (ESI): 475.0 (MH+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08329904B2 |
| Quelldatensatz | uspto-grants-2012_12 |
| ORD ID | ord-f7d038a7947b471782d76ccd613634a0 |
| Quellennotiz | uspto-grants-2012_12 |