Ethanol → 130251-07-9

HRID 2194296Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2194296
S(=O)(=O)(O)O.[Br:6][C@H:7]([CH2:11][CH3:12])[C:8]([OH:10])=[O:9].[CH2:13](O)[CH3:14]>>[Br:6][C@H:7]([CH2:11][CH3:12])[C:8]([O:10][CH2:13][CH3:14])=[O:9]

Komponenten

4

Edukt 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 6992738alpha-Bromobutyric acid, (R)-

Produkt 1

HCID 7000062130251-07-9

Versuchsvorschrift

0.45 mL of sulfuric acid was added to ethanol (70 mL) solution of 7.0 g of (R)-2-bromobutyric acid at room temperature, and refluxed for 3 hours. The reaction mixture was cooled to room temperature, and poured into ice water (140 mL). The solution was extracted 3 times with ethyl acetate. The combined extract was sequentially washed with saturated sodium hydrogen carbonate solution and brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in vacuo, and 7.47 g of the subject compound was prepared as colorless oil. Optical purity 96% ee (HPLC)

Aufarbeitung

  1. temperaturerefluxed for 3 hours
  2. extractionThe solution was extracted 3 times with ethyl acetate
  3. extractionThe combined extract
  4. washwas sequentially washed with saturated sodium hydrogen carbonate solution and brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationAfter filtration
  7. concentrationthe filtrate was concentrated in vacuo, and 7.47 g of the subject compound
  8. customwas prepared as colorless oil

Quellen und Nachweise

ORD-Eintrag
ord-254f7db1dc424391b1abd5787be0b820
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08329913B2

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