[2-(Methylamino)pyridin-3-yl]methanol → 2-(Methylamino)pyridine-3-carbaldehyde

HRID 2194512Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2194512
[CH3:1][NH:2][C:3]1[C:8]([CH2:9][OH:10])=[CH:7][CH:6]=[CH:5][N:4]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][NH:2][C:3]1[N:4]=[CH:5][CH:6]=[CH:7][C:8]=1[CH:9]=[O:10]

Komponenten

4

Edukt 1

HCID 4738518[2-(Methylamino)pyridin-3-yl]methanol

Produkt 1

HCID 31493522-(Methylamino)pyridine-3-carbaldehydeAusbeute 96,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

9.10 g (66.0 mmol) of (2-(methylamino)-3-pyridinyl)methanol was dissolved in chloroform (70 mL), and 17.4 g (200 mmol) of manganese dioxide was added thereto. The mixture was stirred overnight at 60° C. The reaction mixture was filtered, and the filtrate was concentrated. Thus, 8.66 g (yield: 96%) of the title compound was obtained as an orange-colored solid.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-18b9f9a658494078bf6566929d8cdac0
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08334236B2

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