Tetrahydrofuran → 7-Hydroxychromanone

HRID 2194944

Reaktionsgleichung

Reaktionsgleichung von HRID 2194944
O[C:2]1[C:3](=[O:12])[O:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.C1C[O:16]CC1>[OH-].[Pd+2].[OH-]>[OH:16][C:7]1[CH:6]=[C:5]2[C:10]([CH2:11][CH2:2][C:3](=[O:12])[O:4]2)=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 8028TetrahydrofuranHCID 136503-Hydroxycoumarin

Produkt 1

HCID 2981307-Hydroxychromanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 9942167Palladium hydroxideKatalysator

Versuchsvorschrift

A solution of hydroxycoumarin (2.0 g, TCI) in anhydrous THF (50 ml) was added with 10% palladium hydroxide/activated carbon (1.0 g, WAKO), and stirred at room temperature for 2 hours under hydrogen atmosphere. The atmosphere was replaced with nitrogen gas, and then the insoluble matters were removed by filtration through Celite. The solvent was evaporated under reduced pressure to obtain the title compound (2.0 g).

Aufarbeitung

  1. customthe insoluble matters were removed by filtration through Celite
  2. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0874e7d6a25f4b48a3c26f0fa191d965
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08334314B2

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