Hydrochloric Acid → [3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol hydrochloride

HRID 2196455Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2196455
[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([C:11]3[CH:12]=[C:13]([CH2:17][OH:18])[CH:14]=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[C:19]1[S:20][CH:21]=[CH:22][CH:23]=1.[ClH:24]>ClCCl.CO.C(O)(C)C>[ClH:24].[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([C:11]3[CH:12]=[C:13]([CH2:17][OH:18])[CH:14]=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[C:19]1[S:20][CH:21]=[CH:22][CH:23]=1

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 44231018[3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol

Produkt 1

HCID 44231017[3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 3776IsopropanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

140 mg of [3-(3-methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol are suspended in dichloromethane and methanol; 3.2 ml of a 0.1N solution of hydrochloric acid in isopropanol are added thereto, dropwise. The reaction mixture is then concentrated under reduced pressure. The residual solid is taken up in diethyl ether, and the precipitate is recovered by filtration and oven-dried under reduced pressure. 150 mg of compound are obtained.

Aufarbeitung

  1. concentrationThe reaction mixture is then concentrated under reduced pressure
  2. filtrationthe precipitate is recovered by filtration
  3. customoven-dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-15135a70d3f345c7aa492b4069a6eab4
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08338451B2

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