Di-tert-butyl 1-(5-formylthiophen-2-yl)hydrazine-1,2-dicarboxylate → Di-tert-butyl 1-(5-cyanothiophen-2-yl)hydrazine-1,2-dicarboxylate

HRID 2196509Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2196509
[C:1]([C:3]1[S:7][CH:6]=[C:5](N(C(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[CH:4]=1)#[N:2].C(C1SC([N:31]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[NH:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])=CC=1)=O>>[C:1]([C:3]1[S:7][C:6]([N:31]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[NH:32][C:33]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:34])=[CH:5][CH:4]=1)#[N:2]

Komponenten

3

Edukt 2

HCID 59843212Di-tert-butyl 1-(5-formylthiophen-2-yl)hydrazine-1,2-dicarboxylateHCID 59843278Di-tert-butyl 1-(5-cyanothiophen-3-yl)hydrazine-1,2-dicarboxylate

Produkt 1

HCID 59843233Di-tert-butyl 1-(5-cyanothiophen-2-yl)hydrazine-1,2-dicarboxylateAusbeute 75 %

Versuchsvorschrift

Following the same procedure as described for compound 12 (step 2, scheme 2, example 1c) except using 19 (935 mg, 2.73 mmol) instead of 11 to provide compound 20 (692 mg, 75%) as a yellow solid. LRMS (ESI): calc. 339.1; found 340.2 (MH)+.

Quellen und Nachweise

ORD-Eintrag
ord-e891dd38a3ce451e965553d98f67a34a
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08338437B2

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