4-(Trifluoromethyl)aniline → N-[6-Nitro-1-(4-trifluoromethyl-phenylamino)-indan-5-yl]-3-cyclopentyl-propionamide

HRID 2196861Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2196861
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][CH2:9][C:10]2=O)=[CH:6][C:5]=1[NH:14][C:15](=[O:23])[CH2:16][CH2:17][CH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)([O-:3])=[O:2].[F:24][C:25]([F:34])([F:33])[C:26]1[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=1.[B][B][B][B][B][B][B][B][B][B]>CO>[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][CH2:9][CH:10]2[NH:30][C:29]2[CH:31]=[CH:32][C:26]([C:25]([F:24])([F:33])[F:34])=[CH:27][CH:28]=2)=[CH:6][C:5]=1[NH:14][C:15](=[O:23])[CH2:16][CH2:17][CH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)([O-:3])=[O:2]

Komponenten

5

Edukt 3

HCID 99644-(Trifluoromethyl)anilineHCID 59745250N-(6-Nitro-1-oxo-indan-5-yl)-3-cyclopentyl-propionamideHCID 178419135HCID 178419135, Verbindung

Produkt 1

HCID 67243576N-[6-Nitro-1-(4-trifluoromethyl-phenylamino)-indan-5-yl]-3-cyclopentyl-propionamideAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of N-(6-nitro-1-oxo-indan-5-yl)-3-cyclopentyl-propionamide (0.57 g, 1.8 mmol), 4-trifluoromethylaniline (0.35 g, 2.2 mmol), and decaborane (200 mg) in 20 ml of anhydrous methanol was stirred at room temperature overnight. The solvent was removed in vacuo and the residue was purified by column (hexane/EtOAc, 5:1) to give a pure product (0.65 g, 90%).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by column (hexane/EtOAc, 5:1)

Quellen und Nachweise

ORD-Eintrag
ord-d005618bec8844f1918ec8583851933a
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08338487B2

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