Cyanoacetic acid → (1-Ethyl-1,2,3,6-tetrahydropyrid-4-yl)acetonitrile
Reaktionsgleichung
[CH2:1]([N:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1)[CH3:2].[C:10]([CH2:12]C(O)=O)#[N:11]>C1(C)C=CC=CC=1>[CH2:1]([N:3]1[CH2:8][CH:7]=[C:6]([CH2:12][C:10]#[N:11])[CH2:5][CH2:4]1)[CH3:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2.9 g of 1-ethyl-4-piperidone, 3.3 g of cyanoacetic acid and 36 ml of toluene are placed in a round-bottomed flask equipped with a magnetic stirrer, and under a stream of nitrogen. The mixture is refluxed for 4 hours, while removing the water using Markusson apparatus. The solvent is evaporated off under vacuum. 4.2 g of oil are obtained.
Aufarbeitung
- customequipped with a magnetic stirrer
- temperatureThe mixture is refluxed for 4 hours
- customwhile removing the water using Markusson apparatus
- customThe solvent is evaporated off under vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-9a34e0d9277f498ebb1ff39c1fbc7ffc
- Quelldatensatz
- uspto-grants-2012_06
- Patentnummer
- US08202871B2
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