Methyl 4-nitrobutyrate → 8-Benzyloxy-5-hydroxy-4-nitrooctanoic acid methyl ester

Beteiligte Stoffe

Reaktionsschritte

4-benzyloxybutanal (1.463 g, 8.2 mmol), methyl-4-nitrobutyrate (1.29 g, 8.8 mmol) and (−)-sparteine (206 mg, 0.88 mmol) are combined and stirred at RT for 6 hours. EtOAc (5 mL) is added, and the solution is filtered through silica. The solvent is removed in vacuo to yield a pale yellow oil.

Herkunft & Nachweise