Ethanol → HCID 86644293, Verbindung

HRID 2197669

Reaktionsgleichung

Reaktionsgleichung von HRID 2197669
[O:1]=[C:2]1[CH2:6][S:5][C:4](=[S:7])[N:3]1[CH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]1.[C:17]([C:21]1[CH:26]=[CH:25][C:24]([C:27]2[O:31][C:30]([CH:32]=O)=[CH:29][CH:28]=2)=[CH:23][CH:22]=1)([CH3:20])([CH3:19])[CH3:18].C(O)C>CO.ClCCl.[Cl-].[NH4+]>[C:17]([C:21]1[CH:26]=[CH:25][C:24]([C:27]2[O:31][C:30]([CH:32]=[C:6]3[S:5][C:4](=[S:7])[N:3]([CH:8]4[CH2:13][CH2:12][CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]4)[C:2]3=[O:1])=[CH:29][CH:28]=2)=[CH:23][CH:22]=1)([CH3:20])([CH3:19])[CH3:18]

Komponenten

7

Edukt 3

HCID 702EthanolHCID 225667165-(4-Tert-butylphenyl)furan-2-carbaldehydeHCID 594462253-(4-Oxo-2-thioxo-thiazolidin-3-yl)-cyclohexanecarboxylic acid

Produkt 1

HCID 86644293HCID 86644293, VerbindungAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 6344DichloromethaneLösungsmittelHCID 25517Ammonium ChlorideLösungsmittel

Versuchsvorschrift

3-(4-oxo-2-thioxo-thiazolidin-3-yl)-cyclohexanecarboxylic acid (80 mg, 0.31 mmol), 5-(4-tert-butyl-phenyl)-furan-2-carbaldehyde (75 mg, 0.33 mmol), and diethylenediamine diacetate (59 mg, 0.33 mmol) were combined in a 20 mL vial with ethanol (5 mL) and stirred at room temperature for 65 h. The reaction mixture was diluted with 10% methanol in dichloromethane (200 mL) and aqueous ammonium chloride (20 mL) and stirred at room temperature for 15 minutes. The layers were separated and the aqueous layer was extracted with 10% methanol in dichloromethane (2×100 mL). The combined organic extracts were washed with 0.6N sodium hydrogensulfite (1×20 mL) and then brine (1×20 mL), dried (sodium sulfate) and concentrated under vacuum. The residue was triturated with dichloromethane/hexanes (1:5:30 mL), filtered and dried overnight in a vacuum oven at 55° C. to afford 3-{5-[1-[5-(4-tert-butyl-phenyl)-furan-2-yl]-methylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-cyclohexanecarboxylic acid (100 mg, 69%) as a solid. 1H NMR (400 MHz, DMSO-d6): δ 1.32 (9H, s), 1.25-1.41 (2H, m), 1.67 (1H, m), 1.87-1.92 (3H, m), 2.29-2.45 (3H, m), 4.98 (1H, m), 7.26 (1H, d, J=3.6 Hz), 7.36 (1H, d, J=3.6 Hz), 7.59-7.61 (3H, m), 7.77-7.70 (2H, m), 12.20 (1H, s); APCI-MS: 469.52; HPLC: 95%.

Aufarbeitung

  1. stirringstirred at room temperature for 15 minutes
  2. customThe layers were separated
  3. extractionthe aqueous layer was extracted with 10% methanol in dichloromethane (2×100 mL)
  4. washThe combined organic extracts were washed with 0.6N sodium hydrogensulfite (1×20 mL)
  5. dry with materialbrine (1×20 mL), dried (sodium sulfate)
  6. concentrationconcentrated under vacuum
  7. customThe residue was triturated with dichloromethane/hexanes (1:5:30 mL)
  8. filtrationfiltered
  9. customdried overnight in a vacuum oven at 55° C.

Quellen und Nachweise

ORD-Eintrag
ord-bd61bfa78b9b47959c882cc26ba7f4e0
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08338465B2

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