2-Nitro-biphenyl-4-carboxylic acid methyl ester → Methyl 2-amino-[1,1'-biphenyl]-4-carboxylate

HRID 2197970

Reaktionsgleichung

Reaktionsgleichung von HRID 2197970
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:7]([N+:17]([O-])=O)[CH:6]=1)=[O:4]>C(O)C>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[C:7]([NH2:17])[CH:6]=1)=[O:4]

Komponenten

3

Edukt 1

HCID 121698042-Nitro-biphenyl-4-carboxylic acid methyl ester

Produkt 1

HCID 67497797Methyl 2-amino-[1,1'-biphenyl]-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The product from Example 212b (0.0795 g, 0.309 mmol) was dissolved in ethanol (2 mL) and to this solution was added Pt(IV) oxide (5.2 mg). The reaction mixture was vacuum degassed then exposed to one atmosphere of hydrogen for 3 h at room temperature. The catalyst was removed by filtration through celite and the filtrate concentrated under vacuum to give the title compound in quantitative yield.

Aufarbeitung

  1. customdegassed
  2. customThe catalyst was removed by filtration through celite
  3. concentrationthe filtrate concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-0b873e55a0a241748daebcb14bf9074a
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08338605B2

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