Diethylamine → (R)-methyl 2-amino-3-(tritylthio)propanoate

HRID 2198170

Reaktionsgleichung

Reaktionsgleichung von HRID 2198170
[NH:1](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:2]([C:24]([O:26][CH3:27])=[O:25])[CH2:3][S:4][C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(NCC)C>C(#N)C>[NH2:1][C@H:2]([C:24]([O:26][CH3:27])=[O:25])[CH2:3][S:4][C:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Komponenten

4

Edukt 2

HCID 8021DiethylamineHCID 59278482Fmoc-Cys(Trt)-OMe

Produkt 1

HCID 10429690(R)-methyl 2-amino-3-(tritylthio)propanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a solution of Fmoc-L-Cys(Trt)-OMe (2.58 g, 4.30 mmol) in acetonitrile (20.0 mL) was added diethylamine (20.0 mL). After 30 minutes, the mixture was concentrated in vacuo. The residue was dissolved in acetonitrile (3×10 mL) and concentrated in vacuo to afford L-Cys(Trt)-OMe as crude product which was used without purification.

Aufarbeitung

  1. concentrationthe mixture was concentrated in vacuo
  2. dissolutionThe residue was dissolved in acetonitrile (3×10 mL)
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0a74ce79f8564bde89c41e528b96b2e4
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08338610B2

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