Ethyl 2-bromopropionate → ethyl 2-{4-[N-methyl-N-(6,7-dichloro-2-quinoxalinyl)amino]phenoxy}propionate

HRID 2198499

Reaktionsgleichung

Reaktionsgleichung von HRID 2198499
[CH3:1][N:2]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)[C:3]1[CH:12]=[N:11][C:10]2[C:5](=[CH:6][C:7]([Cl:14])=[C:8]([Cl:13])[CH:9]=2)[N:4]=1.Br[CH:23]([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[CH3:1][N:2]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH:23]([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:17][CH:16]=1)[C:3]1[CH:12]=[N:11][C:10]2[C:5](=[CH:6][C:7]([Cl:14])=[C:8]([Cl:13])[CH:9]=2)[N:4]=1

Komponenten

3

Edukt 2

HCID 79040Ethyl 2-bromopropionateHCID 133231424-[N-methyl-N-(6,7-dichloro-2-quinoxalinyl)amino]phenol

Produkt 1

HCID 13323143ethyl 2-{4-[N-methyl-N-(6,7-dichloro-2-quinoxalinyl)amino]phenoxy}propionate

Versuchsvorschrift

4-[N-Methyl-N-(6,7-dichloro-2-quinoxalinyl)amino]phenol was reacted with ethyl 2-bromopropionate, following essentially the same procedure as that described in Example 1 Part (b), to give ethyl 2-{4-[N-methyl-N-(6,7-dichloro-2-quinoxalinyl)amino]phenoxy}propionate, mp 79° C. Proton magnetic resonance spectrum (CDCl3 ; δ in ppm): 8.25 (1H, s, quinoxaline hetero-ring proton); 7.9 (1H, s, quinoxaline benzo-ring proton); 7.8 (1H, s, quinoxaline benzo-ring proton); 7.2 (4H, m, phenoxy protons); 4.85 (1H, q, CH-CH3); 4.3 (2H, q, CH2 -CH3); 3.55 (3H, s, N-CH3); 1.7 (3H, d, CH-CH3); 1.3 (3H, t, CH2 -CH3).

Quellen und Nachweise

ORD-Eintrag
ord-bb5f2f760e524e0c99976d1d839d2a4b
Quelldatensatz
uspto-grants-1982_11
Patentnummer
US04358307

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