3-(Methylsulfonyl)benzonitrile → N'-hydroxy-3-(methylsulfonyl)benzenecarboximidamide

HRID 219887

Reaktionsgleichung

Reaktionsgleichung von HRID 219887
[NH2:1][C:2](=[N:14][OH:15])[C:3]1[CH:12]=[CH:11][C:6](C(OC)=O)=[C:5](F)[CH:4]=1.[CH3:16][S:17](C1C=C(C=CC=1)C#N)(=[O:19])=[O:18]>>[OH:15][N:14]=[C:2]([C:3]1[CH:12]=[CH:11][CH:6]=[C:5]([S:17]([CH3:16])(=[O:19])=[O:18])[CH:4]=1)[NH2:1]

Komponenten

3

Edukt 2

HCID 27610913-(Methylsulfonyl)benzonitrileHCID 76644654Methyl 4-[amino(hydroxyimino)methyl]-2-fluorobenzoate

Produkt 1

HCID 76685351N'-hydroxy-3-(methylsulfonyl)benzenecarboximidamideAusbeute 75 %

Versuchsvorschrift

The title compound was obtained following procedure described for Intermediate 1 step 2 but starting from 3-methylsulfonylbenzonitrile (3.03 g; 16.72 mmol) to give the title compound as a white powder (2.69 g, 75%). 1H NMR (DMSO-d6, 300 MHz) δ 9.88 (s, 1H), 8.21 (t, J=1.68 Hz, 1H), 8.00 (dt, J=1.44, 7.93 Hz, 1H), 7.91 (dt, J=1.49, 7.80 Hz, 1H), 7.66 (t, J=7.84 Hz, 1H), 6.03 (s, 2H), 3.23 (s, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-e6fa662b97d84de6b5641f538e87d07f
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08202865B2

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