Ethanol → Benzoic acid, 4-fluoro-, ethyl ester

HRID 2199

Reaktionsgleichung

Reaktionsgleichung von HRID 2199
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH2:11]([OH:13])[CH3:12]>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:13][CH2:11][CH3:12])=[O:7])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 702EthanolHCID 678794-Fluorobenzoyl chloride

Produkt 1

HCID 67976Benzoic acid, 4-fluoro-, ethyl ester

Versuchsvorschrift

A mixture containing 35 g of 4-fluorobenzoyl chloride in 50 ml of 100% ethanol is refluxed for 15 minutes. 35 g of the ethyl 4-fluorobenzoate obtained are mixed with 22 g of imidazole and 61 g of potassium carbonate in 35 ml of DMSO. The mixture is heated for 18 hours at 120°-130° C. and 500 ml of iced water are then added. A precipitate forms and the expected product crystallizes from iso ether.

Aufarbeitung

  1. temperatureis refluxed for 15 minutes

Quellen und Nachweise

ORD-Eintrag
ord-43d95d9c07ef43d581eb72b8af369b67
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728723

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