Potassium Hydroxide → potassium 2-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]acetate

HRID 2199974Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2199974
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([OH:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[OH-].[K+:25]>C(O)C>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([O-:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[K+:25]

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 60152151HCID 60152151, Verbindung

Produkt 1

HCID 131732622potassium 2-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of the compound [97] (118 mg) in ethanol (5 mL) was added an aqueous solution of 1N-potassium hydroxide (0.34 mL) at room temperature, and then the reaction mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure to give the titled compound (128 mg) as a white solid.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7c38aebe47d747a289d277ba92082e0d
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09359350B2

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