N-(2,3-Epoxypropyl)phthalimide → AGN-PC-0KLTOI

HRID 2201228Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2201228
NC(N)=[S:3].O1[CH2:19][CH:6]1[CH2:7][N:8]1[C:12](=[O:13])[C:11]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:10]2[C:9]1=[O:18]>CO>[S:3]1[CH2:19][CH:6]1[CH2:7][N:8]1[C:12](=[O:13])[C:11]2[C:10](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]1=[O:18]

Komponenten

4

Edukt 2

HCID 21601N-(2,3-Epoxypropyl)phthalimideHCID 2723790Thiourea

Produkt 1

HCID 2828744AGN-PC-0KLTOI

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Thiourea (1.873 g, 24.61 mmol) was added to a solution of N-(2,3-epoxypropyl)phthalimide (2 g, 9.84 mmol) in methanol (25 mL). The mixture was stirred at room temperature for 16 hours, then concentrated under vacuum. The residue was diluted with water (50 ml) and extracted with ethyl acetate (50 ml). The organic extract was washed with brine (50 ml) passed through a hydrophobic frit and evaporated under vacuum. Purification by chromatography on silica, eluting with 0-50% EtOAc/hexane, afforded the title compound.

Aufarbeitung

  1. concentrationconcentrated under vacuum
  2. additionThe residue was diluted with water (50 ml)
  3. extractionextracted with ethyl acetate (50 ml)
  4. extractionThe organic extract
  5. washwas washed with brine (50 ml)
  6. customevaporated under vacuum
  7. customPurification by chromatography on silica
  8. washeluting with 0-50% EtOAc/hexane

Quellen und Nachweise

ORD-Eintrag
ord-153f62342903406099735512a6d2db4a
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09359381B2

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