Sodium hydride → 7-(((tert-Butyldimethylsilyl)oxy)methyl)-9-(4-chlorothiazol-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-8,9-dihydro-1H-pyrimido[4,5-a]pyrrolizine-2,4(3H,7H)-dione

Reaktionsgleichung

[H-].[Na+].CS(O[CH:8]([CH2:18][CH:19]([C:40]1[S:41][CH:42]=[C:43]([Cl:45])[N:44]=1)[C:20]1[NH:21][C:22]([C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[CH:34]=2)=[C:23]2[C:28](=[O:29])[N:27]([CH3:30])[C:26](=[O:31])[N:25]([CH3:32])[C:24]=12)[CH2:9][O:10][Si:11]([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12])(=O)=O>C1COCC1>[Si:11]([O:10][CH2:9][CH:8]1[CH2:18][CH:19]([C:40]2[S:41][CH:42]=[C:43]([Cl:45])[N:44]=2)[C:20]2[N:21]1[C:22]([C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[CH:34]=1)=[C:23]1[C:28](=[O:29])[N:27]([CH3:30])[C:26](=[O:31])[N:25]([CH3:32])[C:24]1=2)([C:14]([CH3:15])([CH3:16])[CH3:17])([CH3:12])[CH3:13]