Hydrochloric Acid → (S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride

HRID 2201716

Reaktionsgleichung

Reaktionsgleichung von HRID 2201716
C(OC([NH:8][C@@H:9]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:10]([NH:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[NH2:8][C@@H:9]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:10]([NH:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 6560406methyl 2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-4-methylpentanamido]acetate

Produkt 1

HCID 18603049(S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a solution of (S)-methyl 2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido) acetate (3w) in 1,4-dioxane was added a 5M solution of HCl in 1,4-dioxane at room temperature. The reaction was stirred at room temperature for 16 h. The reaction mixture was filtered to afford (S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride (4w) as the filtered solid.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered

Quellen und Nachweise

ORD-Eintrag
ord-2252f31280bf45b8a8a34205320c0bf4
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365498B2

Verknüpfte Notizen

Wird geladen…