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N,N,N-Tributylbutan-1-aminium fluoride--hydrogen fluoride (1/1/2) → (E)-[2-(3-{4-[1-(4-Bromo-phenylcarbamoyl)-3-hydroxy-propyl]phenyl}-acryloylamino)-phenyl]carbamic acid tert-butyl ester

HRID 220174
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 220174
[C:1]([O:5][C:6](=[O:46])[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][C:15](=[O:45])/[CH:16]=[CH:17]/[C:18]1[CH:23]=[CH:22][C:21]([CH:24]([C:35](=[O:44])[NH:36][C:37]2[CH:42]=[CH:41][C:40]([Br:43])=[CH:39][CH:38]=2)[CH2:25][CH2:26][O:27][Si](C(C)(C)C)(C)C)=[CH:20][CH:19]=1)([CH3:4])([CH3:3])[CH3:2].CCCC[N+](CCCC)(CCCC)CCCC.F.F.[F-]>C1COCC1>[C:1]([O:5][C:6](=[O:46])[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][C:15](=[O:45])/[CH:16]=[CH:17]/[C:18]1[CH:23]=[CH:22][C:21]([CH:24]([C:35](=[O:44])[NH:36][C:37]2[CH:38]=[CH:39][C:40]([Br:43])=[CH:41][CH:42]=2)[CH2:25][CH2:26][OH:27])=[CH:20][CH:19]=1)([CH3:4])([CH3:2])[CH3:3]
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Komponenten

4

Edukt 2

HCID 11748636N,N,N-Tributylbutan-1-aminium fluoride--hydrogen fluoride (1/1/2)HCID 59238282(E)-[2-(3-{4-[1-(4-Bromo-phenylcarbamoyl)-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-acryloylamino)-phenyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 59238323(E)-[2-(3-{4-[1-(4-Bromo-phenylcarbamoyl)-3-hydroxy-propyl]phenyl}-acryloylamino)-phenyl]carbamic acid tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028
Tetrahydrofuran
Lösungsmittel

Versuchsvorschrift

To a solution of (E)-[2-(3-{4-[1-(4-bromo-phenylcarbamoyl)-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-acryloylamino)-phenyl]-carbamic acid tert-butyl ester (1.6 g, 2.26 mmol) in THF (40 mL) was added tetrabutylammonium dihydrogen trifluoride (1.36 g, 4.52 mmol). This mixture was stirred at room temperature overnight and then evaporated to remove THF. The mixture was dissolved in water and extracted with ethyl acetate (3×30 mL). The combined organic layer was washed with brine, dried with Na2SO4, filtered, and evaporated. The crude product was purified by column chromatography (CH2Cl2:EtOAc=10:1) to get yellow solid product. MS: calc'd 594 (MH+), exp 594 (MH+).

Aufarbeitung

  1. customevaporated
  2. customto remove THF
  3. dissolutionThe mixture was dissolved in water
  4. extractionextracted with ethyl acetate (3×30 mL)
  5. washThe combined organic layer was washed with brine
  6. dry with materialdried with Na2SO4
  7. filtrationfiltered
  8. customevaporated
  9. customThe crude product was purified by column chromatography (CH2Cl2:EtOAc=10:1)
  10. customto get yellow solid product

Quellen und Nachweise

ORD-Eintrag
ord-b32e868c6d2b43aea803d8f3db5e32f9
Quelldatensatz
uspto-grants-2012_06
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08202866B2

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