Hydrochloric Acid → 4-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidine

HRID 2202151Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2202151
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.Cl>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[NH:10][N:9]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 7075709HCID 7075709, Verbindung

Produkt 1

HCID 4491264-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

INTERMEDIATE 7 was obtained by removal of the Boc group of INTERMEDIATE 1 with an acid. To a solution of INTERMEDIATE 1 (2.5 g, 6.92 mmol) in dichloromethane (10 mL) was added 4 M HCl (10 mL, 40 mmol in dioxane). The mixture was stirred at room temperature overnight. Solvent was evaporated under reduced pressure, and the residue was dried under vacuum.

Aufarbeitung

  1. customSolvent was evaporated under reduced pressure
  2. customthe residue was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-cda3817722e7482f9746793aec41522b
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365539B2

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