Thionyl Chloride → 1-Phenyl-cyclopropanecarbonyl chloride

Reaktionsgleichung

[C:1]1([C:7]2([C:10]([OH:12])=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:15])=O>>[C:1]1([C:7]2([C:10]([Cl:15])=[O:12])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

Edukt 2

HCID 24386Thionyl Chloride

HCID 802061-Phenylcyclopropanecarboxylic acid

Produkt 1

HCID 27603721-Phenyl-cyclopropanecarbonyl chloride

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

1-Phenyl-cyclopropanecarboxylic acid (0.5 g, 3.1 mmol), was dissolved in thionyl chloride (10 eq, 0.031 mol, 3.68 g, 2.3 ml), and refluxed at 80° C. for 1.5 hours. Then excess of thionyl chloride was evaporated on the rotary evaporator which yielded a dark-yellowish liquid (1-phenyl-cyclopropanecarbonyl chloride A), which was then cooled to 0° C., under argon.

Aufarbeitung

customThen excess of thionyl chloride was evaporated on the rotary evaporator which

Quellen und Nachweise

ORD-Eintrag: ord-ed53528c209f4d25bd2e6f5417502a4b
Quelldatensatz: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08202901B2

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