Sulfuric acid tetrahydrofuran → HCID 178487612, Verbindung

HRID 2202327Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2202327
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].C1COCC1.[F:11][C:12]1[CH:13]=[C:14]([NH:23][C:24]([C@@H:26]2[N:35]([C:36]([C@@H:38]3[CH2:41][C@H:40]([C:42]([OH:44])=[O:43])[CH2:39]3)=[O:37])[CH2:34][CH2:33][C:32]3[N:31]=[C:30]([O:45][CH3:46])[CH:29]=[CH:28][C:27]2=3)=[O:25])[CH:15]=[C:16]2[C:20]=1[C:19]([CH3:22])([CH3:21])[CH2:18][CH2:17]2>C1COCC1>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[F:11][C:12]1[CH:13]=[C:14]([NH:23][C:24]([C@@H:26]2[N:35]([C:36]([C@@H:38]3[CH2:41][C@H:40]([C:42]([OH:44])=[O:43])[CH2:39]3)=[O:37])[CH2:34][CH2:33][C:32]3[N:31]=[C:30]([O:45][CH3:46])[CH:29]=[CH:28][C:27]2=3)=[O:25])[CH:15]=[C:16]2[C:20]=1[C:19]([CH3:21])([CH3:22])[CH2:18][CH2:17]2

Komponenten

4

Edukt 2

HCID 68124251Sulfuric acid tetrahydrofuranHCID 178487610HCID 178487610, Verbindung

Produkt 1

HCID 178487612HCID 178487612, VerbindungAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

0.126M Sulfuric acid/THF (8.01 mL, 1.01 mmol) solution was added to a solution of cis-3-(((5R)-5-((7-fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl)-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)carbonyl)cyclobutanecarboxylic acid (500 mg, 1.01 mmol) in THF (10 mL) at room temperature. The mixture was concentrated under reduced pressure to dryness, and the solid was collected by filtration with ethyl acetate (10 mL) to give the title compound (548.3 mg, 0.924 mmol, 92%) as a white solid.

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure to dryness
  2. filtrationthe solid was collected by filtration with ethyl acetate (10 mL)

Quellen und Nachweise

ORD-Eintrag
ord-61955618f7a2421bbcb922a1cfb807fe
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365520B2

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