Diisobutylaluminumhydride → 1-(Trifluoromethyl)cyclopropanecarboxaldehyde

HRID 2202672Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2202672
CON(C)[C:4]([C:6]1([C:9]([F:12])([F:11])[F:10])[CH2:8][CH2:7]1)=[O:5].[H-].C([Al+]CC(C)C)C(C)C>C(Cl)Cl>[F:10][C:9]([F:12])([F:11])[C:6]1([CH:4]=[O:5])[CH2:8][CH2:7]1

Komponenten

4

Edukt 2

HCID 21225700DiisobutylaluminumhydrideHCID 57785368N-methoxy-N-methyl-1-(trifluoromethyl)cyclopropane-1-carboxamide

Produkt 1

HCID 574451861-(Trifluoromethyl)cyclopropanecarboxaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a stirred solution of compound A103-1 (164 mg, 0.832 mmol) in DCM (2 mL) was added diisobutylaluminum hydride (1 M in hexane, 1.0 mL, 1.0 mmol) at −78° C. under nitrogen atmosphere. After 0.5 h, the mixture was allowed to warm to 0° C. and stirred for 0.5 h. The reaction mixture was quenched with sat. KHSO4 aq. (10 mL) and extracted with DCM (2×4 mL). The combined organic layers were directly used in the next step without further purification.

Aufarbeitung

  1. customThe reaction mixture was quenched with sat. KHSO4 aq. (10 mL)
  2. extractionextracted with DCM (2×4 mL)
  3. customThe combined organic layers were directly used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-4ab3b65041f245cb860bc5961bff4bed
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365522B2

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