Ethyl 4-(hydroxymethyl)-1,3-thiazole-2-carboxylate → HCID 117762896, Verbindung
Reaktionsgleichung
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[S:6][CH:7]=1>[O-2].[O-2].[Mn+4].C1COCC1>[CH:2]([C:3]1[N:4]=[C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[S:6][CH:7]=1)=[O:1]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
A mixture of ethyl 4-(hydroxymethyl)-1,3-thiazole-2-carboxylate (1.23 g), manganese dioxide (5.71 g) and THF (25 ml) was heated at 50° C. overnight. The inorganic material was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound (1.11 g) as a yellow solid.
Aufarbeitung
- customThe inorganic material was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-13b540fa9a904ad68b560f2fefb8b9a6
- Quelldatensatz
- uspto-grants-2016_06
- Patentnummer
- US09365540B2
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