Triethylamine → 5-Bromo-2-(3-hydroxy-3-methylbutyl)isoindolin-1-one

HRID 2203218Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2203218
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=O)=[C:4]([CH2:12]Br)[CH:3]=1.[NH2:14][CH2:15][CH2:16][C:17]([CH3:20])([OH:19])[CH3:18].CCN(CC)CC>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:10][CH:11]=1)[C:6](=[O:8])[N:14]([CH2:15][CH2:16][C:17]([OH:19])([CH3:20])[CH3:18])[CH2:12]2

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 156491734-Amino-2-methylbutan-2-olHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoate

Produkt 1

HCID 231583295-Bromo-2-(3-hydroxy-3-methylbutyl)isoindolin-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To methyl 4-bromo-2-(bromomethyl)benzoate (0.220 g, 0.714 mmol) suspended in MeOH (6.0 mL) were added 4-amino-2-methylbutan-2-ol (0.077 g, 0.750 mmol) and Et3N (0.156 mL, 1.107 mmol). The mixture was heated to reflux (85° C.) for 24 hours, then cooled to RT, and concentrated in vacuo to give the title compound, which was used without further purification.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperaturecooled to RT
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b4703082cc7f4b1f9aa93a2627270c78
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365566B2

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