Methanol → HCID 59471788, Verbindung

HRID 2204827Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2204827
[NH2:1][C:2]1[C:3]([C:14]([OH:16])=[O:15])=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][N:7]=1.OS(O)(=O)=O.[CH3:22]O>>[NH2:1][C:2]1[C:3]([C:14]([O:16][CH3:22])=[O:15])=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][N:7]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 594721543-Amino-6-(pyridin-3-yl)pyrazine-2-carboxylic acid

Produkt 1

HCID 59471788HCID 59471788, VerbindungAusbeute 97 %

Versuchsvorschrift

To 3-amino-6-(3-pyridyl)pyrazine-2-carboxylic acid (2 g, 9.251 mmol) in MeOH (50 mL) was added conc. H2SO4 (907.3 mg, 493.1 μL, 9.251 mmol) and the mixture heated to reflux for 2 hours. The solvent was removed under vacuum and the mixture neutralised with aqueous Na2CO3 and the resulting solid collected by filtration and dried to give the desired product (2.08 g, 97% Yield). MS (ES+) 231.87

Aufarbeitung

  1. temperaturethe mixture heated
  2. temperatureto reflux for 2 hours
  3. customThe solvent was removed under vacuum
  4. filtrationthe resulting solid collected by filtration
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f0209112058d472d8ab785d12a3d764b
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365557B2

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