Hydrochloric Acid → (S)-tert-butyl 2-(2-aminobutoxy)acetate

HRID 2204987Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2204987
C(OC([NH:8][C@@H:9]([CH2:20][CH3:21])[CH2:10][O:11][CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=O)(C)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[NH2:8][C@@H:9]([CH2:20][CH3:21])[CH2:10][O:11][CH2:12][C:13]([O:15][C:16]([CH3:18])([CH3:17])[CH3:19])=[O:14]

Komponenten

5

Edukt 3

HCID 313Hydrochloric Acid2×HCID 312751,4-Dioxane2×HCID 86678281(S)-tert-butyl 2-(2-(tert-butoxycarbonylamino)butoxy)acetate

Produkt 1

HCID 87385354(S)-tert-butyl 2-(2-aminobutoxy)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (S)-tert-butyl 2-(2-(tert-butoxycarbonylamino)butoxy)acetate (1 eq, from the previous step) in DCM (0.4 M) at room temperature was added a solution of 4 M HCl in dioxane (10 eq). The reaction was stirred for 2 hours, at which time more 4 M HCl in dioxane (3 eq) was added and stirred for 1 hour. The reaction mixture was concentrated en vaccuo to give the product as an oil. The material was carried onto the next step without further purification.

Aufarbeitung

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated en vaccuo

Quellen und Nachweise

ORD-Eintrag
ord-29982f93124d4af4997245f0abfa0b43
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365506B2

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