Sodium hydride → 1-isobutyl-3-methyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

HRID 2205653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2205653
[H-].[Na+].[CH2:3]([N:7]1[CH:12]=[CH:11][C:10](=[O:13])[N:9]([CH3:14])[C:8]1=[O:15])[CH:4]([CH3:6])[CH3:5].C1(C)C=CC(S([CH2:25][N+:26]#[C-:27])(=O)=O)=CC=1>C1COCC1>[CH2:3]([N:7]1[C:12]2=[CH:25][NH:26][CH:27]=[C:11]2[C:10](=[O:13])[N:9]([CH3:14])[C:8]1=[O:15])[CH:4]([CH3:6])[CH3:5]

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 161915Tosylmethyl isocyanideHCID 674157251-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione

Produkt 1

HCID 674156251-isobutyl-3-methyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Sodium hydride (95%, 1.74 g, 69 mmol) is suspended in 20 mL of anhydrous THF, and then a mixture of 1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione (approx. 23 mmol) and p-toluenesulfonylmethyl isocyanide (97%,7.0 g, 35 mmol) in 20 mL of anhydrous THF is added dropwise over 80 minutes at 0° C. The mixture is stirred at room temperature for an hour after the completion of the addition, and then carefully quenched with water. The mixture is diluted with 50 mL of saturated NaHCO3, and then extracted with CH2Cl2 five times. The combined organic phase is washed with brine, and then dried with anhydrous Na2SO4. After filtration, the filtrate is evaporated to dryness under reduced pressure to give product as light brown solids, which is used in the next step without further purification. MS (ESI) m/z 222.2 [M+H]+.

Aufarbeitung

  1. additionis added dropwise over 80 minutes at 0° C
  2. additionafter the completion of the addition
  3. customcarefully quenched with water
  4. additionThe mixture is diluted with 50 mL of saturated NaHCO3
  5. extractionextracted with CH2Cl2 five times
  6. washThe combined organic phase is washed with brine
  7. dry with materialdried with anhydrous Na2SO4
  8. filtrationAfter filtration
  9. customthe filtrate is evaporated to dryness under reduced pressure
  10. customto give product as light brown solids, which
  11. customis used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-edf8ba93038744d0bca5353b1351f01f
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09371327B2

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