Hydrogen chloride-ethyl acetate → 1-(2,6-difluorophenyl)-3-(4-(morpholin-4-yl)phenyl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one hydrochloride

HRID 2206187Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2206187
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N:9]1[C:17]2[CH:16]=[CH:15][NH:14][C:13](=[O:18])[C:12]=2[C:11]([C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[CH:21][CH:20]=2)=[N:10]1.C(OC(=O)C)C.[ClH:37]>C(O)C>[ClH:37].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N:9]1[C:17]2[CH:16]=[CH:15][NH:14][C:13](=[O:18])[C:12]=2[C:11]([C:19]2[CH:20]=[CH:21][C:22]([N:25]3[CH2:26][CH2:27][O:28][CH2:29][CH2:30]3)=[CH:23][CH:24]=2)=[N:10]1

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 1370107601-(2,6-difluorophenyl)-3-(4-(morpholin-4-yl)phenyl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one

Produkt 1

HCID 1370107591-(2,6-difluorophenyl)-3-(4-(morpholin-4-yl)phenyl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 1-(2,6-difluorophenyl)-3-(4-(morpholin-4-yl)phenyl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one (500 mg) obtained in Example 179 in ethanol (4 mL) was added 4M hydrogen chloride ethyl acetate (0.612 mL), and the mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated, and the residue was crystallized from DMSO and ethyl acetate to give the title compound (433 mg).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was crystallized from DMSO and ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-5100fb0c44e34b61a74b05c224b5805c
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09371320B2

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