Hydrochloric Acid → Ethyl {2-amino-2-[3-(trifluoromethyl)phenyl]ethyl}carbamate hydrochloride

HRID 220675Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 220675
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[C:5]([CH:9]([NH:17]C(=O)OC(C)(C)C)[CH2:10][NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15])[CH:6]=[CH:7][CH:8]=1.[ClH:27]>ClCCl.O1CCOCC1>[ClH:27].[NH2:17][CH:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:25])[F:26])[CH:4]=1)[CH2:10][NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 59536750tert-Butyl ethyl {1-[3-(trifluoromethyl)phenyl]ethane-1,2-diyl}biscarbamate

Produkt 1

HCID 86646633Ethyl {2-amino-2-[3-(trifluoromethyl)phenyl]ethyl}carbamate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of 527 mg (1.40 mmol) of the compound from Example 103A in 9.6 ml of dichloromethane was admixed at RT with 9.4 ml (37 mmol) of 4M hydrogen chloride in dioxane and stirred for 1 h. Then all of the volatile constituents were removed on a rotary evaporator. Drying of the residue in an HV gave 437 mg (94% of theory) of the title compound.

Aufarbeitung

  1. customThen all of the volatile constituents were removed on a rotary evaporator
  2. customDrying of the residue in an HV

Quellen und Nachweise

ORD-Eintrag
ord-ac6b2bf161ad426da7a1b50b363000e2
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08202895B2

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