6-Methoxy-alpha-tetralone → (2E)-2-[(3-bromo-4-pyridyl)-methylene]-6-methoxy-tetralin-1-one
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[CH2:8][CH2:7][CH2:6]2.[Br:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][C:20]=1[CH:21]=O>>[Br:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][C:20]=1/[CH:21]=[C:8]1/[C:9](=[O:13])[C:10]2[C:5]([CH2:6][CH2:7]/1)=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=2Komponenten
3
Versuchsvorschrift
The title compound 87 is prepared according to the procedure reported in Example 34.2 with 6-methoxy-1-tetralone (4.74 g, 26.9 mmol) and 3-bromo-4-pyridinecarboxaldehyde (5.0 g, 26.9 mmol) as reactants. White solid. (Yield 7.0 g, 76%).
Quellen und Nachweise
- ORD-Eintrag
- ord-1c1ba8fd640d41209b90be6f84f6ece8
- Quelldatensatz
- uspto-grants-2016_06
- Patentnummer
- US09376387B2