1-(Bromomethyl)-3-chlorobenzene → 2-[[3-Acetyl-1-[(3-chlorophenyl)methyl]pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide
Reaktionsgleichung
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2].[Cl:24][C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH2:28][Br:29]>>[Br-:29].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:28][C:27]2[CH:30]=[CH:31][CH:32]=[C:25]([Cl:24])[CH:26]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2]Komponenten
3
Versuchsvorschrift
The title compound 122 is prepared according to the procedure reported in Example 38.1 with compound 103 (62 mg, 0.2 mmol) and 3-chlorobenzyl bromide (39 μL, 0.3 mmol) as reactants. White solid. (Yield 75.0 mg, 73%).
Quellen und Nachweise
- ORD-Eintrag
- ord-d730c638762145a0b749282d7a91651e
- Quelldatensatz
- uspto-grants-2016_06