4-Azidomethyl-3-fluorobenzoic acid methyl ester → Methyl 4-(aminomethyl)-3-fluorobenzoate
Reaktionsgleichung
[H][H].[CH3:3][O:4][C:5](=[O:17])[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]=[N+]=[N-])=[C:8]([F:16])[CH:7]=1>CO>[CH3:3][O:4][C:5](=[O:17])[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[C:8]([F:16])[CH:7]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Hydrogen was passed through a degassed solution of 4-azidomethyl-3-fluorobenzoic acid methyl ester from Example E3.3 (2.11 g, 10 mmol) in methanol containing 10% palladium on carbon for 2 h. The reaction mixture was filtered through Celite® filter agent and the filtrate was concentrated in vacuo to give a colourless oil identified as the title compound (1.51 g, 83%).
Aufarbeitung
- filtrationThe reaction mixture was filtered through Celite®
- filtrationfilter agent
- concentrationthe filtrate was concentrated in vacuo
- customto give a colourless oil
Quellen und Nachweise
- ORD-Eintrag
- ord-f00fecd360784249b375eaf6613fbb7c
- Quelldatensatz
- uspto-grants-2012_06
- Patentnummer
- US08202858B2
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