Thionyl Chloride → 3-(3-Bromo-4-fluoro-phenyl)-acryloyl chloride

HRID 2207879

Reaktionsgleichung

Reaktionsgleichung von HRID 2207879
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]([OH:13])=O)[CH:5]=[CH:6][C:7]=1[F:8].S(Cl)([Cl:16])=O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]([Cl:16])=[O:13])[CH:5]=[CH:6][C:7]=1[F:8]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 6883113-(3-Bromo-4-fluorophenyl)-2-propenoic acid

Produkt 1

HCID 27569963-(3-Bromo-4-fluoro-phenyl)-acryloyl chloride

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

3-(3-Bromo-4-fluoro-phenyl)-acrylic acid (3.3 g, 13.3 mmol) prepared in Step 1 was added to thionyl chloride (10.0 mL). The reaction mixture was stirred at 100° C. for 2 hours, concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 3.5 g of the titled compound as an unpurified dark brown liquid.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. concentrationThe resulting residue was concentrated under reduced pressure three times, along with using toluene

Quellen und Nachweise

ORD-Eintrag
ord-1bc6024e22d84855b8396c2585ada29d
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09376420B2

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