Thionyl Chloride → HCID 131735941, Verbindung

Reaktionsgleichung

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:13])=[C:6]([CH:8]=[CH:9][C:10](O)=[O:11])[CH:7]=1.S(Cl)([Cl:16])=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:13])=[C:6]([CH:8]=[CH:9][C:10]([Cl:16])=[O:11])[CH:7]=1

Komponenten

Edukt 2

HCID 24386Thionyl Chloride

HCID 6883153-(5-Bromo-2-fluorophenyl)prop-2-enoic acid

Produkt 1

HCID 131735941HCID 131735941, Verbindung

Reaktionsbedingungen

Temperatur: 100 °C

Versuchsvorschrift

3-(5-Bromo-2-fluoro-phenyl)-acrylic acid (1.3 g, 5.0 mmol) prepared in Step 1 was added to thionyl chloride (10.0 mL). The reaction mixture was stirred at 100° C. for 2 hours and then concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 1.4 g of the titled compound as an unpurified dark brown liquid.

Aufarbeitung

concentrationconcentrated under reduced pressure
concentrationThe resulting residue was concentrated under reduced pressure three times, along with using toluene

Quellen und Nachweise

ORD-Eintrag: ord-cb8805a510234eb29b9116e862017cef
Quelldatensatz: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09376420B2

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