Thionyl Chloride → 3-(5-Bromo-pyridin-3-yl)-acryloyl chloride

HRID 2207893Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2207893
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]([OH:12])=O)[CH:5]=[N:6][CH:7]=1.S(Cl)([Cl:15])=O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]([Cl:15])=[O:12])[CH:5]=[N:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 27847353-(5-Bromopyridin-3-yl)prop-2-enoic acid

Produkt 1

HCID 1317359453-(5-Bromo-pyridin-3-yl)-acryloyl chloride

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

3-(5-Bromo-pyridin-3-yl)-acrylic acid (26.2 g, 114.7 mmol) prepared in Step 1 was added to thionyl chloride (100.0 mL). The reaction mixture was stirred at 100° C. for 2 hours and then concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 3-(5-bromo-pyridin-3-yl)-acryloyl chloride as an unpurified dark brown liquid.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. concentrationThe resulting residue was concentrated under reduced pressure three times, along with using toluene

Quellen und Nachweise

ORD-Eintrag
ord-01fe754c286948e4b62d352405604faf
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09376420B2

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