1-methyl-5-(2-nitro-phenylamino)-1H-pyrazole-4-carboxylic acid ethyl ester → ethyl 5-(2-aminophenylamino)-1-methyl-1H-pyrazole-4-carboxylate

Beteiligte Stoffe

Reaktionsschritte

1-Methyl-5-(2-nitro-phenylamino)-1H-pyrazole-4-carboxylic acid ethyl ester (20.8 g, 72 mmol) from Example E11.1 was dissolved in methanol (330 ml) and hydrogenated over 10% Pd/C catalyst for 4 h. The mixture was filtered through Celite® filter agent and the filtrate was concentrated in vacuo to give a white solid identified as the title compound (16.2 g, 87%).

Herkunft & Nachweise