Hydrochloric Acid → Levobunolol Hydrochloride

HRID 22087

Reaktionsgleichung

Reaktionsgleichung von HRID 22087
[CH3:1][C:2]([NH:5][CH2:6][C@H:7]([OH:21])[CH2:8][O:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:19](=[O:20])[CH2:18][CH2:17][CH2:16][C:15]=12)([CH3:4])[CH3:3].[ClH:22]>C(O)C>[CH3:4][C:2]([NH:5][CH2:6][C@H:7]([OH:21])[CH2:8][O:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:19](=[O:20])[CH2:18][CH2:17][CH2:16][C:15]=12)([CH3:1])[CH3:3].[ClH:22]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 39468Levobunolol

Produkt 1

HCID 5284409Levobunolol HydrochlorideAusbeute 51 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To the above toluenic solution containing levobunolol as free base, 16 ml ethanol and the stoichiometric amount of hydrogen chloride were added. The stirred mixture was cooled below 10° C. and kept at this temperature for one hour. The precipitated solid was filtered, washed with toluene, recrystallized twice from 43 ml ethanol and dried to give 10.0 g (51% yield) of levobunolol hydrochloride having a rotary power at 25° C. below -19°.

Aufarbeitung

  1. temperatureThe stirred mixture was cooled below 10° C.
  2. filtrationThe precipitated solid was filtered
  3. washwashed with toluene
  4. customrecrystallized twice from 43 ml ethanol
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6a3b1f99d2ba4f2d923b4e3351667225
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05426227

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